Gene name:
ADAMTS4 (UNQ769/PRO1563;KIAA0688) ;
Protein name:
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4;ADAM-TS4;ADAMTS-4) ;
Alternative:
Aggrecanase-1 ;ADMP-1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SRPX2.
Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
Protein Attributes:
50:
MSQTGSHPGR | GLAGRWLWGA | QPCLLLPIVP | LSWLVWLLLL | LLASLLPSAR |
100:
LASPLPREEE | IVFPEKLNGS | VLPGSGAPAR | LLCRLQAFGE | TLLLELEQDS |
150:
GVQVEGLTVQ | YLGQAPELLG | GAEPGTYLTG | TINGDPESVA | SLHWDGGALL |
200:
GVLQYRGAEL | HLQPLEGGTP | NSAGGPGAHI | LRRKSPASGQ | GPMCNVKAPL |
250:
GSPSPRPRRA | KRFASLSRFV | ETLVVADDKM | AAFHGAGLKR | YLLTVMAAAA |
300:
KAFKHPSIRN | PVSLVVTRLV | ILGSGEEGPQ | VGPSAAQTLR | SFCAWQRGLN |
350:
TPEDSDPDHF | DTAILFTRQD | LCGVSTCDTL | GMADVGTVCD | PARSCAIVED |
400:
DGLQSAFTAA | HELGHVFNML | HDNSKPCISL | NGPLSTSRHV | MAPVMAHVDP |
450:
EEPWSPCSAR | FITDFLDNGY | GHCLLDKPEA | PLHLPVTFPG | KDYDADRQCQ |
500:
LTFGPDSRHC | PQLPPPCAAL | WCSGHLNGHA | MCQTKHSPWA | DGTPCGPAQA |
550:
CMGGRCLHMD | QLQDFNIPQA | GGWGPWGPWG | DCSRTCGGGV | QFSSRDCTRP |
600:
VPRNGGKYCE | GRRTRFRSCN | TEDCPTGSAL | TFREEQCAAY | NHRTDLFKSF |
650:
PGPMDWVPRY | TGVAPQDQCK | LTCQAQALGY | YYVLEPRVVD | GTPCSPDSSS |
700:
VCVQGRCIHA | GCDRIIGSKK | KFDKCMVCGG | DGSGCSKQSG | SFRKFRYGYN |
750:
NVVTIPAGAT | HILVRQQGNP | GHRSIYLALK | LPDGSYALNG | EYTLMPSPTD |
800:
VVLPGAVSLR | YSGATAASET | LSGHGPLAQP | LTLQVLVAGN | PQDTRLRYSF |
837:
FVPRPTPSTP | RPTPQDWLHR | RAQILEILRR | RPWAGRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
ELISA Kit for Human ADAM-TS 4
ELISA Kit for Human ADAM-TS 4
ELISA Kit for Human ADAM-TS 4
ELISA Kit for Human ADAM-TS 4
CLIA Kit for Human ADAM-TS 4
CLIA Kit for Human ADAM-TS 4
CLIA Kit for Human ADAM-TS 4
CLIA Kit for Human ADAM-TS 4
Polyclonal Antibody for Human ADAM-TS 4
Polyclonal Antibody for Human ADAM-TS 4
Polyclonal Antibody for Human ADAM-TS 4
Polyclonal Antibody for Human ADAM-TS 4
Monoclonal Antibody for Human ADAM-TS 4
Monoclonal Antibody for Human ADAM-TS 4
Monoclonal Antibody for Human ADAM-TS 4
Monoclonal Antibody for Human ADAM-TS 4
Protein for Human ADAM-TS 4
Protein for Human ADAM-TS 4
Protein for Human ADAM-TS 4
Protein for Human ADAM-TS 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Y Zha, Y Chen, F Xu, et al.
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Cited for : X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 213-520 ALONE AND IN COMPLEX WITH INHIBITOR;ACTIVE SITE;COFACTOR;ZINC-BINDING SITES;DISULFIDE BONDS